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Chemical Characteristics of Testosterone Cypionate
As previously mentioned, Testosterone Cypionate is simply Testosterone with the Cypionate ester bound to the Testosterone chemical structure. Specifically ‘Cypionate’ is Cypionic acid, but once bound to Testosterone it is properly referred to in chemistry as an ester bond (or ester linkage). Cypionic acid is chemically bound to the 17-beta hydroxyl group on the Testosterone structure. Esterified anabolic hold a greater degree of solubility in fats, and therefore release slower from the injection site in comparison to un-esterified Testosterone – however, this is not the main reason as to why esters extend the release rate and half-life of the given anabolic steroid it is attached to. The primary reason for the augmentation of its half-life and release rate is due to the fact that when Testosterone Cypionate enters the bloodstream, enzymes will bind to the Testosterone Cypionate molecule and break the bond between the ester and the hormone, which takes a varying amount of time depending on the size of the ester in question. This is why larger esters such as Cypionate, Enanthate, Decanoate, and so forth all possess longer half-lives than the smaller shorter esters such as Propionate, Phenylpropionate, Acetate, etc. Therefore, the end result is that the ester is removed from the hormone via enzymes, and what is left over following this chemical interaction is pure Testosterone that is free to do its work in the body. This process of enzymes cleaving off the ester from the Testosterone molecule is what is ultimately responsible for the slower release rates. Pure Testosterone alone with no ester bonded to it possesses a half-life of approximately 2 – 4 hours. When the Cypionate ester is attached to it, creating Testosterone Cypionate, the half-life of Testosterone is now extended to 12 days, which results in a slower release and activity of the hormone.
Testosterone Cypionate’s attributes and expressive properties follows what any individual would expect from Testosterone preparation, with the exception of the differing release rates and half-lives. It must be made clear right now to the reader that Testosterone is very much literally the original anabolic steroid, which is manufactured endogenously naturally in all humans and in the vast majority of animal species. Two important facts result from this: 1. Testosterone is utilized as the base measurement by which all other anabolic steroids are measured against, and, 2. Because Testosterone is the most natural anabolic steroid already manufactured by the human body, Testosterone is considered the safest anabolic steroid for use, as every individual’s body is already accustomed to the effects of Testosterone only to a lesser degree. Essentially, the use of Testosterone for the purpose of physique and performance enhancement is simply the supplementation of additional Testosterone – this could easily be defined as the practice of administering (either through injection or ingestion) more of a hormone into the body that it already manufactures and utilizes.
Where side effects are concerned, Testosterone Cypionate could be described as being moderate. It is often compared to its almost identical brother, Testosterone Enanthate. The truth of the matter is that Testosterone Cypionate has a longer half-life due to its longer fatty acid ester chain, which does modulate its side effect profile ever so slightly, but this is really a matter of splitting hairs and never noticeable. At its core, it is a Testosterone variant and therefore will carry with it all of the side effects known to Testosterone. Testosterone is the primary male hormone manufactured in humans and in all vertebrates, and is the father of all anabolic steroids. Of course, when it comes to any discussion of side effects, one must take into account that there will be varying differences between individuals due to factors such as individual body reaction, age, sensitivity, and genetics. These are all factors that determine whether someone may experience certain side effects at a greater or lesser degree, or whether they may not experience these side effects at all.
Estrogenic side effects are the first and primary concern that almost all anabolic steroid users consider and research surrounding Testosterone Cypionate. Testosterone itself is known for being an aromatizable anabolic steroid (meaning, it converts – aromatizes – into Estrogen in the body). The aromatization rate of Testosterone Cypionate in relation to other anabolic steroids is moderate at best. The rate of aromatization is also heavily dependent on the dosage, and thus the total blood plasma levels of Testosterone at any one given time. The general rule is that more Testosterone equals more aromatization into Estrogen. Potential estrogenic side effects include the following: water retention and bloating, increases in blood pressure (resultant from water retention), increased fat gain/retention, and potential development of gynecomastia.
Being that Testosterone Cypionate is an androgen, users are also susceptible to androgenic side effects as well. Testosterone is also known for its reduction to a much more powerful androgen, Dihydrotestosterone (DHT), in the body – particularly in higher degrees in various tissues, such as the scalp, prostate, and skin. This is where the real bulk of the androgenic side effects come from, as opposed to Testosterone’s direct interaction with androgen receptors itself. Potential androgenic side effects include the following: increased oily skin (sebum secretion), increased acne formation (linked to sebum secretion), bodily and facial hair growth, and the increased risk of experiencing male pattern baldness (MPB) if the individual possesses the genetic predisposition for it.
Much like Testosterone Enanthate, Testosterone Cypionate has been found in studies to exert absolutely no hepatotoxic (liver toxic) activity in the body, even when administered orally at what would be considered extreme doses.
Because Testosterone is, of course, an androgenic anabolic steroid, it does impose suppression and shutdown of the hypothalamic testicular pituitary axis (HPTA) during use. In other words, it will cause the body to stop manufacturing its own natural endogenous Testosterone. Other known potential side effects that follow Testosterone Cypionate use include negative cardiovascular impacts, most notably the reduction of ‘good’ (HDL) cholesterol in the bloodstream during use.
As with almost any Testosterone variant or derivative, Testosterone Cypionate cycles tend to almost always be utilized for the purpose of bulking, mass gaining, and strength gaining periods of training. Though its ideal use is for this purpose, this is not to say that it cannot be used effectively (albeit at a lower dosage) for cutting cycles where fat loss is the primary goal. For the purpose of bulking and/or gaining mass and strength, Testosterone Cypionate is usually employed at a higher dosage (approximately 500mg/week). It is usually utilized at this dosage for a period of 12 – 14 weeks due to its longer ester, and therefore longer half-life. Testosterone Cypionate possesses a half-life of around 10 – 12 days. By comparison, its close counterpart Testosterone Enanthate is almost the same, with a half-life of around 7 – 10 days.
No matter the cycle goal, whether it is cutting or bulking, Testosterone Cypionate is usually utilized with and stacked with other anabolic steroids that possess very similar characteristics for obvious reasons. It is a common companion to compounds such as Nandrolone Decanoate, which is usually run for the same 10 – 12 week length as Testosterone Cypionate, and a ‘kickstarting’ compound such as Methandrostenolone is usually included from the start of the cycle until it is discontinued at around week 4 or 6.
Medically, Testosterone Cypionate is prescribed at 250mg once every 2 – 4 weeks, which is also dependent on the physician’s protocol, and the patient’s progress in his TRT therapy.
In the realm of bodybuilding and performance enhancement, Testosterone Cypionate is normally run at around 300 – 500mg weekly as a beginner dosage range. Intermediate Testosterone Cypionate dosages are often in the range of 500 – 750mg per week, and advanced users are known for running as high as 1,000mg or more per week of Testosterone Cypionate.
As Testosterone Cypionate possesses a half-life of around 10 – 12 days, it is recommended that Testosterone Cypionate is administered once per week at an absolute minimum. However, if one wishes to experience the best results possible, ideally Testosterone Cypionate would be administered two times per week where the dosage is split evenly between injections. For example, a Testosterone Cypionate dosing of 500mg/week should be administered as 250mg on Monday and 250mg on Thursday every week. This minimizes peaks and valleys in blood plasma levels, and thus also reduces certain unwanted side effects due to spiking blood plasma levels of the hormone.
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